About the authorPaul VegasShare the loveHave your say Kurt Zouma: Chelsea kids play with no fearby Paul Vegas19 days agoSend to a friendShare the loveKurt Zouma says Chelsea’s young team are still adjusting to eachother’s games.Zouma is relatively new to this particular Chelsea side, which he acknowledges is a work in progress.”We are improving a lot,” the central defender told chelseafc.com. “Last year there were some players out on loan who have come back, like me, so you need time to settle everything. We are getting better and better.”The young guys are here to bring something new, and the older guys are here to calm things down, stop the young guys getting too excited too quickly, and give advice on dealing with the pressure. We have a very strong team because we have that mix. It can be good for everyone.”We have a very young squad but they are talented at the same time. You can see all the guys, Fikayo, Tammy, Mason, Reece who started his first game, have no fear. They just play their football.”All the guys are ready to give advice and help. We are a team. For me they are ready to compete in every game. They will be very important to help the team keep going forward. They have the quality and you can see from the way they’re playing they’re doing very well.”We have a good mix of young and old, everybody speaks to everybody.”
New Delhi: Prime Minister Narendra Modi Saturday urged his supporters to take the ‘main bhi chowkidar’ (I too am watchman) pledge and said he was not alone in the fight against graft and social evils, drawing ridicule from Congress president Rahul Gandhi. “Your Chowkidar is standing firm & serving the nation. But, I am not alone. Everyone who is fighting corruption, dirt, social evils is a Chowkidar. Everyone working hard for the progress of India is a Chowkidar. Today, every Indian is saying-#MainBhiChowkidar,” the prime minister wrote on Twitter. Also Read – Squadrons which participated in Balakot air strike awarded citations on IAF Day He also posted a short video to drive home his message. Soon after, Gandhi mocked Modi and tweeted, “Defensive tweet Mr Modi! You feeling a little guilty today” while a tagging a picture of Modi along with businessmen such as Vijay Mallya, Nirav Modi and Mehul Choksi, Anil Ambani and Gautam Adani. The Congress president earlier alleged that Modi only served the interests of his industrialist-friends. Modi has often described himself as a “chowkidar” who would neither allow corruption nor get corrupted himself. Also Read – Don’t use ‘lynching’ to defame India: Bhagwat Gandhi has been repeatedly hurling the “chowkidar chor hai” (watchman is the thief) jibe at Modi to claim irregularities and favouritism in the Rafale fighter jet deal, a charge the BJP-led government has rejected. Congress chief spokesperson Randeep Surjewala hit back at Modi accusing him of being the “only chowkidar who is a thief”. “One who wears a suit worth Rs 10 lakh and who helps Bank fraudsters Modi-Mehul-Mallya, one who wasts public money to the tune of Rs 52,000 crore for his own propaganda, one who spends Rs 2,010 crore to travel to 84 countries on people’s money and one who helped in theft of Rs 30,000 crore in rafale jet deal, only one Chowkidar is a thief,” he said in a tweet in Hindi.
The No. 16-ranked Ohio State Buckeyes (3-0) will close out their non-conference schedule this Saturday, Sept. 22, when they host the University of Alabama at Birmingham. Coach Urban Meyer discussed his team’s upcoming opponent and Big Ten conference woes during the Big Ten coaches weekly teleconference Tuesday. Blazing Downfield Through two games, UAB (0-2) has been anything but prolific on offense. The Blazers rank 110th of 124 teams nationally in points scored, and failed to find the end zone last weekend against South Carolina. Nonetheless, Meyer said UAB poses concerns for his defense, particularly in the passing game. “They just throw it down the field a lot,” Meyer said. The Buckeyes have struggled defending aerial attacks so far this season, allowing an average of more than 283 passing yards per game. “We’ve seen enough big plays for a season, yet alone just three games,” Meyer said. “And this team is willing to launch it down the field. That’s an issue.” Big Problem for the Big Ten? In recent years Big Ten teams have struggled to compete nationally, consistently losing high-profile non-conference games and struggling during bowl season. The trend has continued this season. Only three teams in the conference remain undefeated, and at No. 16, Ohio State is the conference’s highest ranked team in the latest Associated Press Top 25 poll. Meyer said there is only one way for Big Ten teams to silence the criticism and prove that they are among the nation’s elite conferences. “There’s one answer, go win those non-conference games,” Meyer said. “It’s not because of a lack of players or lack of coaching, they just have to find a way to close the deal. And I think they will.” Meyer said he hasn’t had a chance to watch much Big Ten football yet this season, but believes that there is still plenty of talent in the conference. “It’s a long season,” Meyer said. “There are a lot of things that will happen. I think there are a lot of great football teams in the Big Ten conference and I’m sure they will start to surface here real soon.”
Ohio State freshman midfielder Sage Darling receives a pass in the offensive zone against Rutgers on March 25. Credit: Courtesy of OSUThe Ohio State women’s lacrosse team (6-8) have not had the easiest path to get where it is at this point in the season, and it is not going to get any easier. The Buckeyes have three games remaining against three of the best teams in the country: No. 17 Northwestern, No. 1 Maryland and Johns Hopkins, who sits just outside the 20th spot in the Inside Lacrosse Poll.While OSU began to get its offense back on track against No. 6 Penn State — scoring 12 goals for the first time since March 7 — they will need to summon even more production in the remainder of their games. “I thought we had some good chemistry on the attack,” coach Alexis Venechanos said of the team’s loss to the Nittany Lions. “I thought we limited our turnovers in the midfield, and when you’re playing these conference games, those little details are going to matter.”Northwestern has, historically, been dominant against the Buckeyes, winning 13 of the 16 previous matchups, with OSU’s most recent win coming in a 2014 overtime game. Venechanos spent three years on the Wildcats’ staff (2004 to 2006) as an assistant, so it means a lot to her for them to be one of the big rivals in their conference. “It was a great learning experience. I learned a lot on the field and off the field,” Venechanos said. “(Northwestern coach Kelly Amonte Hiller) is a great competitor. She taught me how to compete, and I’m glad we have an opportunity to play them every year.”Hiller has led the Wildcats to seven NCAA championships, with last season being the first year that they had not reached at least the NCAA quarterfinals in 14 years. While Northwestern’s record at first glance is similar to the Buckeyes at 6-6, the Wildcats’ schedule has been stacked with great competition. The Buckeyes will still be without freshman midfielder Liza Hernandez, but they can still be capable of generating offense. Junior attacker Molly Wood and sophomore midfielder Baley Parrott have both stepped up to lead their team in scoring.“We’re working on ourselves right now,” Wood said. “We’re working on the little things, the fundamentals and to see those getting better is huge for our team.”OSU will be looking to continue its development as the season winds down, but Venechanos said they are most excited for the present. “We’ve challenged our players to get a little bit better from the previous week, the previous day and even in the drill we are doing — let’s get better this time,” Venechanos said. “We’re moving some people around, they’re stepping up.”The game is set for a 7 p.m. start time on Thursday, in what will be OSU’s first game of the season at Jesse Owens Memorial Stadium.
(Phys.org) —A fundamental question in the evolution of animal body plans, is where did the head come from? In animals with a clear axis of right-left symmetry, the bilaterians, the head is where the brain is, at the anterior pole of the body. Little is known about the possible ancestor of bilaterians. Fortunately their sister group from that same progenitor, the cnidarians, can be studied in parallel today to give some clues. Cnidarians are creatures like jellyfish, hydra, and sea anemone which possess rudimentary nerve nets, but no clear brain. They all have just a single orifice to the external world, which basically does it all. In a recent paper published in PLOS Biology, researchers from the University of Bergen in Norway compared gene expression patterns in sea anemone (Nematostella vectensis, Nv) with that from a variety of bilaterian animals. They found that the head-forming region of bilaterians is actually derived from the aboral, the opposite-oral, side of the ancestral body plan. Pioneering developmental biologist Lewis Wolpert, is often credited with having observed: “It is not birth, marriage, or death, but gastrulation which is truly the most important time in your life.” Almost all animals undergo a similar gastrulation process early in their development. The point where the cells first invaginate during gastrulation, the blastopore, uniquely defines an embryonic axis. After this stage however, all bets are off—attempts to define phyla according to hardline criteria, like blastopore = anus, are invariably met by counterexample where it instead becomes the mouth. Gene expression, while not always constrained into single contiguous areas, therefore provides a baggage-free way to assign homology across species.Wolpert’s concept of positional information in development has been largely vindicated by the discovery of hox gene codes in a wide variety of animals. While hox genes are the critical regulators of axial patterning, in most bilaterians they are not expressed in the anterior head-forming region. The researchers focused instead on the genes six3 and FoxQ2, transcription factors which have been shown to regulate anterior-posterior development. Six3 knockouts in mice, for example, fail to develop a forebrain. In humans six3 regulates forebrain and eye development.Sea anemone, like Nematosella, are curious creatures. As larvae they swim about with their aboral pole forward. As adults they plunge this region into the sea floor, and permanently anchor themselves in. Their bodies then undergo various changes but their oral pole remains intact for feeding. By using knockdown and rescue experiments in Nemostella, the researchers were able to show that six3 is required for the development of the aboral region, and the expression of further regulatory genes. This suggests that the region distal from the cnidarian mouth parallels development of the bilaterian head. The researchers also looked at the expression of the forkhead domain protein foxQ2, which functions downstream of six3. Forkhead box genes are an important class of transcription factors which frequently lack the signature homeodomains and zinc-finger regions common to other transcription factors. Instead they have a unique DNA-binding region that has the shape of a winged helix. The forkhead gene, fox2p, in humans has recently garnered a lot of media attention for its apparent role in neural development, and in even more esoteric functions like speech development. FoxQ2 is known to be a well-conserved marker for the most anterior tip of a variety of bilaterians including sea urchines, drosophila, and cephalochordates. The researchers established that before gastrulation in cnidarians, foxQ2a was expressed in the aboral pole, and in a small number cells resembling neurons. Afterwards the expression of this “ring gene” was excluded from a central spot. In conclusion, the expression of genes for anemone head development, away from the mouth region, suggests that head development came first and was a separate event from mouth development. Secondarily, the head and a coalescing brain appear to have merged to become a centralized control center. Where does our head come from? Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2013 Phys.org Journal information: PLoS Biology Citation: Which came first the head or the brain? (2013, March 28) retrieved 18 August 2019 from https://phys.org/news/2013-03-brain_1.html More information: Sinigaglia C, Busengdal H, Leclère L, Technau U, Rentzsch F (2013) The Bilaterian Head Patterning Gene six3/6 Controls Aboral Domain Development in a Cnidarian. PLoS Biol 11(2): e1001488. doi:10.1371/journal.pbio.1001488AbstractThe origin of the bilaterian head is a fundamental question for the evolution of animal body plans. The head of bilaterians develops at the anterior end of their primary body axis and is the site where the brain is located. Cnidarians, the sister group to bilaterians, lack brain-like structures and it is not clear whether the oral, the aboral, or none of the ends of the cnidarian primary body axis corresponds to the anterior domain of bilaterians. In order to understand the evolutionary origin of head development, we analysed the function of conserved genetic regulators of bilaterian anterior development in the sea anemone Nematostella vectensis. We show that orthologs of the bilaterian anterior developmental genes six3/6, foxQ2, and irx have dynamic expression patterns in the aboral region of Nematostella. Functional analyses reveal that NvSix3/6 acts upstream of NvFoxQ2a as a key regulator of the development of a broad aboral territory in Nematostella. NvSix3/6 initiates an autoregulatory feedback loop involving positive and negative regulators of FGF signalling, which subsequently results in the downregulation of NvSix3/6 and NvFoxQ2a in a small domain at the aboral pole, from which the apical organ develops. We show that signalling by NvFGFa1 is specifically required for the development of the apical organ, whereas NvSix3/6 has an earlier and broader function in the specification of the aboral territory. Our functional and gene expression data suggest that the head-forming region of bilaterians is derived from the aboral domain of the cnidarian-bilaterian ancestor.Synopsys: www.plosbiology.org/article/in … journal.pbio.1001484